SCR7 pyrazine

CAS No. 14892-97-8

SCR7 pyrazine( SCR7 pyrazine | SCR-7 pyrazine | SCR 7 pyrazine )

Catalog No. M17321 CAS No. 14892-97-8

SCR7 is a specific DNA Ligase IV inhibitor, which blocks nonhomologous end-joining (NHEJ).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SCR7 pyrazine
  • Note
    Research use only, not for human use.
  • Brief Description
    SCR7 is a specific DNA Ligase IV inhibitor, which blocks nonhomologous end-joining (NHEJ).
  • Description
    SCR7 pyrazine is an inhibitor of nonhomologous end-joining (NHEJ), enhancing CRISPR-Cas9-mediated homology-directed repair (HDR) in vitro.
  • In Vitro
    SCR7 pyrazine (20-100 μM; 24 hours; MCF7 cells) treatment interferes with NHEJ in cells, leading to accumulation of unrepaired double-strand breaks (DSBs).SCR7 pyrazine treatment shows a dose-dependent decrease in cell proliferation with IC50 values of 40 μM, 34 μM, 44 μM, 8.5 μM, 120 μM, 10 μM and 50 μM for MCF7, A549, HeLa, T47D, A2780, HT1080 and Nalm6 cells, respectively.In MCF7 cells, SCR7 pyrazine (20, 40 μM) treatment increases phosphorylation of ATM and activates p53, decreases MDM2, BCL2, resulting in activation of proapoptotic proteins, PUMA and BAX. And the shorter fragments of MCL1, PARP1, Caspase 3, and Caspase 9 cleavage are upregulated in a dose-dependent manner. Western Blot Analysis Cell Line:MCF7 cells Concentration:20 μM, 40 μM, 100 μM Incubation Time:24 hours Result:Showed an increase in levels of gH2AX foci and protein.
  • In Vivo
    SCR7 pyrazine (10 mg/kg; intraperitoneal injection; six doses; BALB/c mice) treatment significantly reduces breast adenocarcinoma-induced tumor and increases lifespan. Animal Model:BALB/c mice injected with breast adenocarcinoma cells Dosage:10 mg/kg Administration:Intraperitoneal injection; on alternate days (0, 2, 4, 6, 8, and 10)Result:Significantly reduced breast adenocarcinoma-induced tumor and increased lifespan.
  • Synonyms
    SCR7 pyrazine | SCR-7 pyrazine | SCR 7 pyrazine
  • Pathway
    Endocrinology/Hormones
  • Target
    CaMK
  • Recptor
    DNALigase IV
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    14892-97-8
  • Formula Weight
    332.38
  • Molecular Formula
    C18H12N4OS
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (300.86 mM)
  • SMILES
    O=c1[nH]c(=S)[nH]c2c1nc(c1ccccc1)c(n2)c1ccccc1
  • Chemical Name
    2,3-Dihydro-6,7-diphenyl-2-thioxo-4(1H)-pteridinone

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Srivastava M, et al. Cell. 2012, 151(7), 1474-1487.
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